SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity.

 

UNC84B

 

Mouse IgG

 

70 kDa

 

Human

 

This Abmart monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of human SUN2

 

Store at -20°C, stable for one year from the date of shipment.

 

Western blotting        1:1000-1:5000                     
Immunoprecipitation     10 tests                
FACS                    1:100-1:200