Catalog No: CY5032 Reactivity: Human
Isotype: Rabbit IgG Applications: WB, IHC-P, ICC/IF, FC
UniProt ID: P10415
All Names: Apoptosis regulator Bcl-2; BCL2
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 26 kDa
WB: 1:500~1:2000
IHC: 1:50~1:100
ICC/IF: 1:50~1:100
FC: 1:50
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Western blot analysis of Bcl-2 expression in (1) Jurkat cell lysate; (2) MCF-7 cell lysate.