Catalog No: CY5580 Reactivity: Human Mouse
Isotype: Rabbit IgG Applications: WB ICC/IF
UniProt ID: P35354
All Names: COX2; COX-2; Cyclooxygenase 2; PGH2; PGHS2; PHS2; TIS10; PTGS2;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 69 kDa
WB: 1:500~1:1000
ICC/IF: 1:50~1:200
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes,resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Western blot analysis of COX2 expression in RAW264.7
cell lysate treated with LPS.