Catalog No: CY7035 Reactivity: Human Mouse Rat
Isotype: Rabbit IgG Applications: WB IHC ICC/IF FC
UniProt ID: O60313
All Names: Large GTP binding protein; largeG; MGM1; Mitochondrial dynamin like GTPase; NPG; NTG;OAK; OPA 1;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 85kDa
WB 1:500~1:2000
IHC 1:50~1:200
ICC/IF 1:50~1:200
FC 1:50
Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C(CYCS) into the mitochondrial intermembrane space.

Western blot analysis of OPA1 expression in HeLa cell
lysate.