Catalog No: CY5253 Reactivity: Human
Isotype: Rabbit IgG Applications: WB, IHC
UniProt ID: P08962
All Names: CD63 antigen; Melanoma-associated antigen ME491; Ocular melanoma-associated antigen; OMA81H; Granulophysin; Tetraspanin-30; Tspan-30; Lysosomal-associated membrane protein 3; Lamp-3; CD63; MLA1; TSPAN30
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 26 kDa
WB 1:1000~1:2000
IHC 1:500~1:1000
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2.

Western blot analysis of CD63 expression in A375 cell lysate.