Catalog No: CY5939 Reactivity: Human Mouse
Isotype: Rabbit IgG Applications: WB FC
UniProt ID: Q99466
All Names: NOTC4; hNotch4; INT3; Notch homolog 4;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 210 kDa
WB 1:100~1:500
FC 1:50
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching
morphogenesis in the developing vascular system (By similarity).

Western blot analysis of NOTCH4 expression in Mouse
lung lysate.