Catalog No: CY5797 Reactivity: Human
Isotype: Rabbit IgG Applications: WB IHC ICC/IF IP FC
UniProt ID: Q04912
All Names: c met related tyrosine kinase; CD136 antigen; Macrophage stimulating 1 receptor; MSP receptor;
p185 RON; PTK 8; PTK8 protein tyrosine kinase 8; RON protein tyrosine kinase; Stem cell derived tyrosine
kinase; MST1R variant RON30; MST1R variant RON62;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 185 kDa
WB 1:1000~1:2000
IHC 1:50~1:200
ICC/IF 1:50~1:200
IP 1:30
FC 1:30
Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa α chain and a 150 kDa β chain.Ron is initially synthesized in the cells as a single-chain, pro-Ron precursor that is cleaved into the two active chains. RON signaling activates the wound healing response by promoting epithelial cell migration,proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages.

Western blot analysis of RON expression in SKBR3 cell lysate.