Catalog No: CY5138 Reactivity: Human, Mouse
Isotype: Rabbit IgG Applications: WB IHC ICC/IF FC
UniProt ID: P16070
All Names: CD44 antigen precursor, CDw44, ECMR-III, Epican, Extracellular matrix receptor-III, GP90
lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate
receptor, LHR, PGP-1, Phagocytic glycoprotein I
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: Synthesized peptide
Molecular Wt.: 82kDa
WB: 1:500~1:2000
IHC: 1:50~1:200
ICC/IF: 1:50~1:200
FC: 1:50
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and  possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix
metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and posttranslational modification events.

Western blot analysis of extracts from TF-1 cells, using CD44 antibody.