Catalog No: CY6598 Reactivity: Human
Isotype: Rabbit IgG Applications: WB IHC
UniProt ID: P11279
All Names: Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1;
LAMP-1; CD107 antigen-like family member A; CD107a; LAMP1;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 120 kDa
WB 1:500~1:2000
IHC 1:50~1:200
LAMP1 and LAMP2 (lysosome-associated membrane protein 1 and 2) are two abundant lysosomal membrane proteins. Both are transmembrane proteins and heavily glycosylated at the amino-terminal luminal side of the lysosomal inner leaflet, which protects the proteins from proteolysis. The carboxy terminus of LAMP1 is exposed to the cytoplam and contains a tyrosine sorting motif which targets LAMP to lysosomal membranes. LAMP1 and LAMP2 are 37% homologous in their protein sequences. The cellular functions of these two proteins are also overlap - both are involved in regulating lysosomal motility during lysosomephagosome fusion and cholesterol trafficking.

Western blot analysis of LAMP1 expression in A431 cell lysate.