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| 信号通路Signaling-PARP1 (2G10) Mouse mAb
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Background
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP- ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular
processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, PARP1 may be the site of mutation in Fanconi anemia, and may
participate in the pathophysiology of type I diabetes.
Source
This Abmart monoclonal antibody is produced by immunizing mice with a polypeptide (Abmart SEAL mAb technology) corresponding to surface multi-epitopes of human PARP1.
Specificity
PARP1 monoclonal antibody detects endogenous levels of PARP1 protein.
Storage
Store at -20°C, stable for one year from the date of shipment.
Predicted Molecular Weight
Applications
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WB analysis endogenous of PARP1 in extracts from various cell lines:
Lane1-4: Hela, 293T, COS-7, F9
Primary antibody 1:1000
Reactivity
Human, Monkey, Mouse, Chinese Hamster, Dog, Rat
Isotype
Secondary Antibodies
Use an anti-MOUSE secondary antibody.
Application Tested
Western blotting 1: 1000-1: 2000
Immunofluorescence 1:100-1:500
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