Catalog No: CY6936 Reactivity: Human Mouse
Isotype: Rabbit IgG Applications: WB IHC ICC FC
UniProt ID: Q53EL6
All Names: Death up-regulated gene protein; Dug; H731; Ma3; Neoplastic transformation inhibitor; Nuclear antigen H731; Pdcd4; Programmed cell death protein 4; Tis;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 52kDa
WB 1:500~1:2000
IHC 1:100~1:500
ICC/IF 1:50~1:200
FC 1:50
PDCD4 (programmed cell death protein 4) was identified as a suppressor of neoplastic transformation. It interacts with eukaryotic initiation factors eIF4AI and eIF4AII. PDCD4 colocalizes with eIF4A in the cytoplasm and inhibits the activity of eIF4A as an ATP-dependent RNA helicase.

Western blot analysis of PDCD4 expression in HeLa cell lysate.