Catalog No: CY6638 Reactivity: Human Mouse Rat
Isotype: Rabbit IgG Applications: WB IHC ICC/IF
UniProt ID: O95140
All Names: CMT2A2; CMT2A; CPRP1; MFN2; Hyperplasia suppressor; MARF; Mitofusin 2; HSG;
Transmembrane GTPase MFN2; Mitofusin-2;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 80 kDa
WB 1:500~1:2000
IHC 1:50~1:200
ICC/IF 1:50~1:200
Mitofusins are mitochondrial transmembrane GTPases that function to regulate mitochondrial fusion, a process that occurs in concert with mitochondrial division and is necessary for the maintenance of structural and genetic mitochondrial integrity. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
 

Western blot analysis of Mitofusin 2 expression in (1)
HeLa cell lysate; (2) Mouse kidney lysate.
For