Catalog No: CY6614 Reactivity: Human
Isotype: Rabbit IgG Applications: WB IP FC
UniProt ID: Q8IWA4
All Names: MFN1; Fzo homolog; Hfzo2; Mitofusin-1; Hfzo1; Mitofusin1; Putative transmembrane GTPase;
Transmembrane GTPase MFN1;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 84 kDa
WB 1:1000~1:5000
IP 1:20
FC 1:20
Mitofusins are mitochondrial transmembrane GTPases that function to regulate mitochondrial fusion, a
process that occurs in concert with mitochondrial division and is necessary for the maintenance of structural
and genetic mitochondrial integrity. Two mitofusins have been described in mammals, mitofusin-1 and -2,
which share 60% amino acid identity and appear to function coordinately to regulate mitochondrial fusion.
Mitochondrial fusion is widely recognized as important for normal cell growth and development, and may have evolved as a mechanism to offset the deleterious effects of mtDNA mutations. Null mutations in either mitofusin are embryonic lethal in mice, whereas conditional knockout studies have shown that combined deletion of mitofusin-1 and mitofusin-2 in skeletal muscle results in severe mitochondrial dysfunction.

Western blot analysis of Mitofusin1 expression in K562
cell lysate.