Catalog No: CY5224 Reactivity: Human Mouse
Isotype: Rabbit IgG Applications: WB ICC/IF IP
UniProt ID: P42336
All Names: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; PI3-kinase p110 alpha; PI3K; PI3K p110-alpha; PK3CA; PtdIns-3-kinasep110
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 110 kDa
WB: 1:1000~1:2000
ICC/IF: 1:50~1:200
IP: 1:20
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(Phosphatidylinositol),PtdIns4P(Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generatephosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth,survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.

Western blot analysis of PI 3 kinase p110 alpha
expression in Jurkat cell lysate.