Catalog No: CY5733 Reactivity: Human
Isotype: Rabbit IgG Applications: WB IP
UniProt ID: Q06187
All Names: AGMX1; Tyrosine-protein kinase BTK; BTK; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase; ATK; BPK;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 76 kDa
WB 1:500~1:1000
IP 1:20
Btk plays an important role in B lymphocyte development, differentiation and signaling. Activation of B cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane-localized Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223.

Western blot analysis of BTK expression in Daudi cell lysate.