Catalog No: CY5262 Reactivity: Human Mouse Rat
Isotype: Rabbit IgG Applications: WB ICC/IF IP FC ChIP
UniProt ID: P60484
All Names: CRK1; CSAID binding protein; CSBP; CSBP1; CSBP2; Cytokine suppressive anti- inflammatory drug binding protein; EC 2.7.11.24; MAP kinase MXI2; MAP kinase p38; MAPK14;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 42 kDa
WB 1:500~1:2000
ICC/IF 1:50~1:200
IP 1:50
FC 1:30
ChIP 1:50
Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6.

Western blot analysis of p38 expression in (1) HeLa cell lysate; (2) NIH/3T3cell lysate; (3) PC-12 cell lysate.