Catalog No: CY5490 Reactivity: Human Mouse Rat Cow Dog Monkey Zebrafish
Isotype: Rabbit IgG Applications: WB ICC/IF IP
UniProt ID: P45983/P45984/P53779
All Names: c-Jun N-terminal kinase 3; FLJ12099; FLJ33785; JNK1; JNK2;JNK3; JNK3 alpha protein kinase;
JNK3A; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; MAPK10;
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 46,54kDa
WB: 1:1000~1:2000
ICC/IF: 1:50~1:200
IP: 1:50
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation,migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines
or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling
pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and
activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily
components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity.

Western blot analysis of JNK1/2/3 Antibody expression
in HeLa cell lysate.