Catalog No: CY5113 Reactivity: Human Mouse
Isotype: Rabbit IgG Applications: WB IHC IP FC
UniProt ID: P09601
All Names: HO-1; HSP32; bK286B10; HMOX1
Form: Liquid
Storage instructions: Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage buffer: pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity: Affinity-chromatography
Immunogen: A synthesized peptide
Molecular Wt.: 32 kDa
WB: 1:500~1:2000
IHC: 1:50~1:200
IP: 1:50
Hemeoxygenase (HO) is the rate-limiting enzyme in the catabolism of heme that results in the release of carbon monoxide, iron, and biliverdin. The products of this enzymatic reaction play important biological roles in antioxidant, anti-inflammatory and cytoprotective functions. Hemeoxygenase comprises two isozymes,including the constitutively expressed HO-2 isozyme and the inducible HO-1 isozyme. Inducible HO-1 is expressed as an adaptive response to several stimuli, including heme, metals, and hormones. The induction of HO-1 has been implicated in numerous disease states, such as transplant rejection, hypertension,atherosclerosis, Alzheimer disease, endotoxic shock, diabetes, inflammation, and neurological disorders.

Western blot analysis of Heme Oxygenase 1 in mouse spleen lysate.